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In vitro and in vivo studies have confirmed a high biocompatibility of zirconia, especially when it is completely purified of its radioactive contents. (Gahlert et al., 2007; Andreiolli et al., 2009). Generally, ceramics are inert materials, which have no adverse local or general tissue reactions. As the ceramic prostheses are made with highly polished surface, they can contact the gum tissue and assist in the maintenance of gingival architecture. Depending on the smoothness, the ceramics prevent the buildup of plaque, creating a favorable surface for the gingival tissues. Zirconia based ceramics are chemically inert materials, allowing good cell adhesion, and while no adverse systemic reactions have been associated with it. (Ichikawa et al., 1992). (责任编辑：) |