Tryngolza is a brand-name solution for subcutaneous injection. It’s prescribed for high triglyceride levels related to a certain genetic condition. Tryngolza contains the active ingredient olezarsen.

Specifically, the Food and Drug Administration (FDA) has approved Tryngolza to lower triglyceride levels in adults with familial chylomicronemia syndrome (FCS). It’s prescribed along with a low fat diet.

Drug details

You’ll find key information about Tryngolza here:

Tryngolza generic

Tryngolza is available only as a brand-name medication. It’s not currently available in generic form.

A generic drug is an exact copy of the active ingredient in a brand-name medication. Generics usually cost less than brand-name drugs.

Tryngolza dosage

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug form and strength

Tryngolza comes as a liquid solution in prefilled, single-use autoinjectors. It’s given as a subcutaneous injection under the skin of your abdomen or front thigh. A caregiver may inject the drug under the skin of your upper arm. Your doctor will show you or your caregiver how to give Tryngolza injections.

Tryngolza is available in one strength of 80 milligrams in 0.8 milliliters of solution (mg/mL).

To learn more about how to use Tryngolza, talk with your doctor.

»You can also visit the drug manufacturer’s website.

Dosage for high triglycerides related to FCS

Tryngolza is prescribed to lower triglyceride levels in adults with familial chylomicronemia syndrome (FCS).

For this use, you’ll give yourself one injection (80 mg) of Tryngolza each month.

About using Tryngolza

You’ll find information about key dosage issues here:

Overdose

Do not use more Tryngolza than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.

What to do in case you take too much Tryngolza

If you think you’ve injected too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number or go to the nearest emergency room right away.

Tryngolza side effects

Tryngolza can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while using Tryngolza. These lists do not include all possible side effects.

For more information about the possible side effects of Tryngolza, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while receiving Tryngolza and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.

Mild side effects

Here is a partial list of mild side effects of Tryngolza. To learn about other mild side effects, talk with your doctor or pharmacist or view Tryngolza’s prescribing information.

Mild side effects of Tryngolza can include:

Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Serious side effects from Tryngolza weren’t reported in the drug’s clinical trials. However, they can still occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or you think you’re having a medical emergency.

ALLERGIC REACTION

For some people, Tryngolza can cause an allergic reaction.

In general, symptoms of an allergic reaction can be mild or serious.

Ways to manage

For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They’ll also let you know whether you should keep receiving the medication.

For severe allergic reaction symptoms, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care because they can become life threatening. If you’ve had a serious allergic reaction to Tryngolza, your doctor may recommend a different medication instead.

Tryngolza uses

Tryngolza for high triglycerides related to FCS

Trygolza is approved by the Food and Drug Administration (FDA) to lower triglyceride levels in adults with familial chylomicronemia syndrome (FCS).

FCS is a genetic (inherited) condition that prevents the body from properly breaking down triglycerides. This leads to very high triglyceride levels, which can build up in the blood and increase the risk of pancreatitis (inflammation of the pancreas). Other symptoms of FCS may include abdominal pain, nausea, and fatty deposits under the skin.

For this purpose, Tryngolza is prescribed along with a low fat diet.

To learn more about Tryngolza for FCS, talk with your doctor.

Tryngolza and children

Trygolza is not approved by the FDA for use in children. It isn’t known whether the drug is safe or effective for children.

Tryngolza interactions

Tryngolza is not known to interact with other medications, herbs, supplements, foods, or alcohol. The manufacturer did not list any interactions in the drug’s prescribing information.

However, this doesn’t mean that interactions won’t be recognized in the future. For example, the FDA could approve new drugs that interact with Tryngolza.

Before starting Tryngolza treatment, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you take. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

Tryngolza cost and coupons 

As with all medications, the cost of Tryngolza can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Financial and insurance assistance: If you need financial support to pay for Tryngolza or need help understanding your insurance coverage, help is available.

A program called Ionis Every Step is available for Tryngolza. For more information and to find out if you’re eligible for support, call 844-789-8744 or visit the program website.

Generic version: Tryngolza is not available in a generic form. A generic drug is an exact copy of the active ingredient in a brand-name medication. Generics tend to cost less than brand-name drugs.

»Learn more about saving money on prescriptions.

Things to consider when injecting Tryngolza 

If you can become pregnant, consider the following information about pregnancy and breastfeeding.

Tryngolza and pregnancy

It’s not known whether Tryngolza should be used during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before using this medication.

Tryngolza and breastfeeding

It’s not known whether Tryngolza should be used while breastfeeding. If you’re currently breastfeeding or planning to do so, talk with your doctor before using this medication.

Tryngolza precautions

Before using Tryngolza, discuss your health history with your doctor. Tryngolza may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:

Note: For more information about the potential negative effects of Tryngolza, see the “Tryngolza side effects” section.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.