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Expert Panel Members - Guidelines for the Diagnosis and Management of Asthma 2007 (EPR-3)
Chair William W. Busse, M.D. Homer A. Boushey, M.D. Carlos A. Camargo, M.D., Dr. P.H. David Evans, Ph.D., A.E.-C. Michael B. Foggs, M.D. Susan Janson, D.N.Sc., R.N. H. William Kelly, Pharm.D. Robert F. Lemanske, M.D. Fernando D. Martinez, M.D. Robert J. Meyer, M.D. Harold S. Nelson, M.D. Thomas A.E. Platts-Mills, MD, PhD Michael Schatz, M.D., M.S. Gail Shapiro, M.D.† Stuart Stoloff, M.D. Stanley Szefler, M.D. Scott T. Weiss, M.D., M.S. Barbara P. Yawn, M.D., M.Sc. †Deceased Financial and Other Disclosures - Guidelines for the Diagnosis and Management of Asthma 2007 (EPR-3)
Development of the resource document and the guidelines report was funded by the NHLBI, NIH. Expert Panel members completed financial disclosure forms, and the Expert Panel members disclosed relevant financial interests to each other prior to their discussions. Expert Panel members participated as volunteers and were compensated only for travel expenses related to the Expert Panel meetings. Financial disclosure information covering the 3 year period during which the guidelines were developed is provided for each Panel member below. Dr. Busse has served on the Speakers' Bureaus of GlaxoSmithKline, Merck, Novartis, and Pfizer; and on the Advisory Boards of Altana, Centocor, Dynavax, Genentech/Novartis, GlaxoSmithKline, Isis, Merck, Pfizer, Schering, and Wyeth. He has received funding/grant support for research projects from Astellas, AstraZeneca, Centocor, Dynavax, GlaxoSmithKline, Novartis, and Wyeth. Dr. Busse also has research support from the NIH. Dr. Boushey has served as a consultant for Altana, Protein Design Lab, and Sumitomo. He has received honoraria from (Boehringer-Ingelheim, Genentech, Merck, Novartis, and Sanofi Aventis, and funding/grant support for research projects from the NIH. Dr. Camargo has served on the Speakers' Bureaus of AstraZeneca, GlaxoSmithKline, Merck, and Schering Plough; and as a consultant for AstraZeneca, Critical Therapeutics, Dey Laboratories, GlaxoSmithKline, MedImmune, Merck, Norvartis, Praxair, Respironics, Schering Plough, Sepracor, and TEVA. He has received funding/grant support for research projects from a variety of Government agencies and not-for-profit foundations, as well as AstraZeneca, Dey Laboratories, GlaxoSmithKline, MedImmune, Merck, Novartis, and Respironics. Dr. Evans has received funding/grant support for research projects from the NHLBI. Dr. Foggs has served on the Speakers' Bureaus of GlaxoSmithKline, Merck, Pfizer, Sepracor, and UCB Pharma; on the Advisory Boards of Alcon, Altana, AstraZeneca, Critical Therapeutics, Genentech, GlaxoSmithKline, and IVAX; and as consultant for Merck and Sepracor. He has received funding/grant support for research projects from GlaxoSmithKline. Dr. Janson has served on the Advisory Board of Altana, and as a consultant for Merck. She has received funding/grant support for research projects from the NHLBI. Dr. Kelly has served on the Speakers' Bureaus of AstraZeneca and GlaxoSmithKline; and on the Advisory Boards of AstraZeneca, MAP Pharmaceuticals, Merck, Novartis, and Sepracor. Dr. Lemanske has served on the Speakers' Bureaus of GlaxoSmithKline and Merck, and as a consultant for AstraZeneca, Aventis, GlaxoSmithKline, Merck, and Novartis. He has received honoraria from Altana, and funding/grant support for research projects from the NHLBI and NIAID. Dr. Martinez has served on the Advisory Board of Merck and as a consultant for Genentech, GlaxaSmithKline, and Pfizer. He has received honoraria from Merck. Dr. Meyer has no relevant financial interests. Dr. Nelson has served on the Speakers' Bureaus of AstraZeneca, GlaxoSmithKline, Pfizer, and Schering Plough; and as a consultant for Abbott Laboratories, Air Pharma, Altana Pharma US, Astellas, AstraZeneca, Curalogic, Dey Laboratories, Dynavax Technologies, Genentech/Novartis, GlaxoSmithKline, Inflazyme Pharmaceuticals, MediciNova, Protein Design Laboratories, Sanofi-Aventis, Schering Plough, and Wyeth Pharmaceuticals. He has received funding/grant support for research projects from Altana, Astellas, AstraZeneca, Behringer, Critical Therapeutics, Dey Laboratories, Epigenesis, Genentech, GlaxoSmithKline, Hoffman LaRoche, IVAX, Medicinova, Novartis, Sanofi-Aventis, Schering Plough, Sepracor, TEVA, and Wyeth. Dr. Platts-Mills has served on the Advisory Committee of Indoor Biotechnologies. He has received funding/grant support for a research project from Pharmacia Diagnostics. Dr. Schatz has served on the Speakers' Bureaus of AstraZeneca, Genentech, GlaxoSmithKline, and Merck; and as a consultant for GlaxoSmithKline on an unbranded asthma initiative. He has received honoraria from AstraZeneca, Genentech, GlaxoSmithKline and Merck. He has received funding/grant support for research projects from GlaxoSmithKline and Merck and Sanofi-Adventis. Dr. Shapiro† served on the Speakers' Bureaus of AstraZeneca, Genentech, GlaxoSmithKline, IVAX Laboratories, Key Pharmaceuticals, Merck, Pfizer Pharmaceuticals, Schering Corporation, UCB Pharma, and 3M; and as a consultant for Altana, AstraZeneca, Dey Laboratories, Genentech/Novartis, GlaxoSmithKline, ICOS, IVAX Laboratories, Merck, Sanofi-Aventis, and Sepracor. She received funding/grant support for research projects from Abbott, AstraZeneca, Boehringer Ingelheim, Bristol-Myers-Squibb, Dey Laboratories, Fujisawa Pharmaceuticals, Genentech, GlaxoSmithKline, Immunex, Key, Lederle, Lilly Research, MedPointe Pharmaceuticals, Medtronic Emergency Response Systems, Merck, Novartis, Pfizer, Pharmaxis, Purdue Frederick, Sanofi-Aventis, Schering, Sepracor, 3M Pharmaceuticals, UCB Pharma, and Upjohn Laboratories. Dr. Stoloff has served on the Speakers' Bureaus of Alcon, Altana, AstraZeneca, Genentech, GlaxoSmithKline, Novartis, Pfizer, Sanofi Aventis, and Schering; and as a consultant for Alcon, Altana, AstraZeneca, Dey, Genentech, GlaxoSmithKline, Merck, Novartis, Pfizer, Sanofi Aventis, and Schering. Dr. Szefler has served on the Advisory Boards of Altana, AstraZeneca, Genentech, GlaxoSmithKline, Merck, Novartis, and Sanofi Aventis; and as a consultant for Altana, AstraZeneca, Genentech, GlaxoSmithKline, Merck, Novartis, and Sanofi Aventis. He has received funding/grant support for a research project from Ross. Dr. Weiss has served on the Advisory Board of Genentech, and as a consultant for Genentech and GlaxoSmithKline. He has received funding/grant support for research projects from GlaxoSmithKline. Dr. Yawn has served on the Advisory Boards of Altana, AstraZeneca, Merck, Sanofi Aventis, and Schering Plough. She has received honoraria from Pfizer and Schering Plough, and funding/grant support for research projects from the Agency for Healthcare Research and Quality, the CDC, the NHLBI, Merck, and Schering Plough. †Deceased Evidence Tables - Guidelines for the Diagnosis and Management of Asthma 2007 (EPR-3)
Evidence tables were prepared for a wide range of topics in this comprehensive review. You may download the evidence tables below in PDF format. You need the Acrobat Reader to open the files Information for visitors using screen readers Assessment and Monitoring: Predictors of Exacerbation Assessment and Monitoring: Usefulness of Peak Flow Measurement Patient/Provider Education: Asthma Self-Management Education for Adults Patient/Provider Education: Asthma Self-Management Education for Children Patient/Provider Education: Asthma Self-Management Education in Community Settings Patient/Provider Education: Cost-Effectiveness of Asthma Self-Management Education Patient/Provider Education: Methods for Improving Clinical Behaviors -- Implementing Guidelines Patient/Provider Education: Methods for Improving Systems Support Control of Factors Affecting Asthma: Allergen Avoidance Control of Factors Affecting Asthma: Immunotherapy Pharmacologic Therapy: Inhaled Corticosteroids -- Combination Therapy Pharmacologic Therapy: Inhaled Corticosteroids -- Dosing Strategies Pharmacologic Therapy: Immunomodulators -- Anti-Immunoglobulin E Pharmacologic Therapy: Leukotriene Receptor Antagonist Monotherapy/Effectiveness Studies Pharmacologic Therapy: Bronchodilators -- Safety of Long-Acting Beta2-Agonists Pharmacologic Therapy: Bronchodilators -- Levalbuterol Managing Exacerbations: Increasing the Dose of Inhaled Corticosteroids Managing Exacerbations: IV Aminophylline Managing Exacerbations: Magnesium Sulfate Managing Exacerbations: Heliox Changes to the Guidelines - Guidelines for the Diagnosis and Management of Asthma 2007 (EPR-3)
The EPR-3 was initially posted to the NHLBI website in August 2007. Periodically edits are made to this document and these edits are logged onto this change page. As of August 5, 2008 the following edits have been made (specific wording changes are indicated in bold): PageFigure or TableChanges75Figure 3-5a: Assessing Asthma Control in Children 0 - 4 Years of Age Under the heading Well Controlled, Nighttime awakenings - change to read: "one time or less per month" 311Figure 4-4a: Usual Dosages for Long-Term Control Medications in Children Under the heading, Systemic Corticosteroids, ages 0 to 4 years - change to read: Short-course "burst": 1 - 2 mg/kg/day, maximum 60mg/day for 3 - 10 days. 315Figure 4-4b: Estimated Comparative Daily Dosages for Inhaled Corticosteroids in Children (continued) Under the first bullet, 3rd dash - replace text to read: The doses for budesonide and fluticasone MDI or DPI are based on recently available comparative data. These new data, including meta-analyses, show that fluticasone requires one-half the microgram dose of budesonide DPI to achieve comparable efficacy(Adams et al. 2005; Barnes et al. 1998; Nielsen and Dahl 2000). 318Figure 4-4c: Usual Dosages for Quick-Relief Medications in Children (continued) Under the heading, Systemic Corticosteroids, ages 5 - 11 years - change to read: Short-course "burst":1-2 mg/kg/day, maximum 60 mg/dayfor 3 - 10 days. 349Figure 4-8b: Estimated Comarative Daily Dosages for Inhaled Corticosteroids for Youths 12 Years of Age or Older and Adults Under the last bullet, 3rd dash - replace text to read: The doses for budesonide and fluticasone MDI or DPI are based on recently available comparative data. These new data, including meta-analyses, show that fluticasone requires one-half the microgram dose of budesonide DPI to achieve comparable efficacy(Adams et al. 2005; Barnes et al. 1998; Nielsen and Dahl 2000). 387Figure 5-5: Dosages of Drugs for Asthma Exacerbations Under the heading, Anticholinergics, Ipratropium bromide nebulizer solution - change to read: 0.25 -0.5mg every 20 minutes for 3 doses, then as needed 387Figure 5-5: Dosages of Drugs for Asthma Exacerbations Under the heading Anticholinergics, Iptratropium with albuterol nebulizer solution - change to read: 1.5 -3.0mL every 20 minutes for 3 doses, then as needed 387Figure 5-5: Dosages of Drugs for Asthma Exacerbations Under the heading, Systemic Corticosteroids, Prednisone - change to read: 1 -2mg/kg in 2 divided doses (maximum = 60 mg/day) until PEF is 70% of predicted or personal best Last updated: August 5, 2008 (责任编辑：) |